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Literature summary for 6.3.2.61 extracted from

  • Bodakuntla, S.; Yuan, X.; Genova, M.; Gadadhar, S.; Leboucher, S.; Birling, M.C.; Klein, D.; Martini, R.; Janke, C.; Magiera, M.M.
    Distinct roles of alpha- and beta-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration (2021), EMBO J., 40, e108498 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate Mus musculus overall reaction [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
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 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate overall reaction Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
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 ?

Synonyms

Synonyms Comment Organism
TTLL1
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 Mus musculus

General Information

General Information Comment Organism
malfunction deletion of isoform TTLL1 prevents degeneration of Purkinje cells and of myelinated axons in peripheral nerves ine mice lacking the deglutamylase CCP1. Moreover, loss of TTLL1 leads to increased mitochondria motility in neurons Mus musculus
physiological function isoform TLL1 catalyses the excessive hyperglutamylation found in mice lacking the deglutamylase CCP1 Mus musculus