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Literature summary for 6.3.2.61 extracted from

  • Wang, L.; Paudyal, S.; Kang, Y.; Owa, M.; Liang, F.; Spektor, A.; Knaut, H.; Sanchez, I.; Dynlacht, B.
    Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly (2022), Cell Res., 32, 190-209.
    View publication on PubMed
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General Stability

General Stability Organism
C11ORF49/CSTPP1 regulates the assembly and stability of the enzyme complex and thereby modulates polyglutamylation of microtubule, which antagonizes MAP4 binding Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
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 Homo sapiens
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retinal pigment epithelium cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
TPGC
-
 Homo sapiens
TTL1 catalytic subunit Homo sapiens
tubulin polyglutamylase complex comprised of a catalytic subunit, tubulin tyrosine ligase-like 1, and four additional subunits, tubulin polyglutamylase complex subunits 1 and 2, leucine rich repeat containing 49 and nicolin 1 Homo sapiens
tubulin tyrosine ligase-like 1 catalytic subunit Homo sapiens

General Information

General Information Comment Organism
malfunction loss of the tubulin polyglutamylase complex leads to aberrant, enhanced assembly of microtubules that penetrate the nucleus, which in turn leads to defects in nuclear shape, and disorganization of cytoplasmic actin that disrupts the YAP/TAZ pathway and cilium disassembly Homo sapiens
physiological function the enzyme plays mechanistically distinct roles in the regulation of nuclear shape and cilium disassembly Homo sapiens