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Literature summary for 6.3.2.61 extracted from

  • van Dijk, J.; Rogowski, K.; Miro, J.; Lacroix, B.; Edde, B.; Janke, C.
    A targeted multienzyme mechanism for selective microtubule polyglutamylation (2007), Mol. Cells, 26, 437-448.
    View publication on PubMed
Search for more literature for 6.3.2.61

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information TTLL6_N705 is a stable and enzymatically active truncated protein version. Unlike the full-length enzyme TTLL6, the truncated protein does not localize to cilia Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cilium
-
 Mus musculus 5929
-
flagellar basal body
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q91V51
-
-
Mus musculus Q8CHB8
-
-
Mus musculus A4Q9E8
-
-
Mus musculus A4Q9F4
-
-
Mus musculus A4Q9F6
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain high expression Mus musculus
-
MDCK cell TTLL5 localizes to both basal bodies and cilia Mus musculus
-
MDCK cell TTLL6 localizes to both basal bodies and cilia Mus musculus
-
neuron
-
 Mus musculus
-
testis high expression Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information TTLL1 is an alpha-tubulin preferring polyglutamylase. TTLL1 is solely active as part of a multiprotein complex, that can potentially contain exchangeable regulatory subunits Mus musculus ?
-
 ?
n ATP + [alpha-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate no initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards alpha-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate high initiating activity, low elongation activity. High activity with alpha-tubulin, low activity with beta-tubulin. Upon overexpression in HeLa cells, TTLL5 modifies mostly alpha-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate low initiating activity, high elongation activity. High activity with alpha-tubulin, low activity with beta-tubulin. Upon overexpression in HeLa cells, TTLL5 modifies mostly alpha-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate low initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards alpha-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate no initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards alpha-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate high initiating activity, low elongation activity. High activity with alpha-tubulin, low activity with beta-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate low initiating activity, high elongation activity. High activity with alpha-tubulin, low activity with beta-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate low initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards alpha-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Synonyms

Synonyms Comment Organism
TTLL1 isoform Mus musculus
TTLL11 isoform Mus musculus
TTLL13 isoform Mus musculus
TTLL5 isoform Mus musculus
ttll6 isoform Mus musculus
tubulin polyglutamylase
-
 Mus musculus