Cloned (Comment) | Organism |
---|---|
- |
Tetrahymena thermophila |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cilium | Ttll9p is mainly localized in cilia | Tetrahymena thermophila | 5929 | - |
flagellar basal body | Ttll1p localizes primarily to the basal bodies of oral and somatic cilia | Tetrahymena thermophila | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tetrahymena thermophila | I7MCG4 | - |
- |
Tetrahymena thermophila | Q23SI8 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Tetrahymena thermophila |
partial | Tetrahymena thermophila |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + alpha tubulin + L-glutamate | Ttll1p glutamylase preferentially modifies alpha-tubulin. It shows a chain-initiating activity | Tetrahymena thermophila | ? | - |
? | |
ATP + alpha tubulin + L-glutamate | Ttll9p glutamylase preferentially modifies alpha-tubulin. It has primarily a chain-elongating activity | Tetrahymena thermophila | ? | - |
? | |
ATP + alpha tubulin + L-glutamate | Ttll9p glutamylase preferentially modifies alpha-tubulin. It has primarily a chain-elongating activity | Tetrahymena thermophila SB210 | ? | - |
? | |
ATP + alpha tubulin + L-glutamate | Ttll1p glutamylase preferentially modifies alpha-tubulin. It shows a chain-initiating activity | Tetrahymena thermophila SB210 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ttll1p | - |
Tetrahymena thermophila |
Ttll9p | - |
Tetrahymena thermophila |
General Information | Comment | Organism |
---|---|---|
malfunction | disruption of the TTLL1 and TTLL9 genes decreases the rates of cell multiplication and phagocytosis. Cells lacking both genes had fewer cortical microtubules and show defects in the maturation of basal bodies | Tetrahymena thermophila |
malfunction | disruption of the TTLL1 and TTLL9 genes decreases the rates of cell multiplication and phagocytosis. Cells lacking both genes have fewer cortical microtubules and show defects in the maturation of basal bodies | Tetrahymena thermophila |
physiological function | glutamylation on alpha-tubulin is not essential but is required for efficiency of assembly and function of a subset of microtubule-based organelles. Furthermore, the spatial restriction of modifying enzymes (TTLL1 and TTLL9) appears to be a major mechanism that drives differential glutamylation at the subcellular level | Tetrahymena thermophila |
physiological function | glutamylation on alpha-tubulin is not essential but is required for efficiency of assembly and function of a subset of microtubule-based organelles. Furthermore, the spatial restriction of modifying enzymes appears to be a major mechanism that drives differential glutamylation at the subcellular level | Tetrahymena thermophila |