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Literature summary for 6.3.2.6 extracted from

  • Suparmin, A.; Kato, T.; Dohra, H.; Park, E.Y.
    Insight into cordycepin biosynthesis of Cordyceps militaris comparison between a liquid surface culture and a submerged culture through transcriptomic analysis (2017), PLoS ONE, 12, e0187052 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.6

Cloned(Commentary)

Cloned (Comment) Organism
gene CCM_02686, quantitative expression analysis Cordyceps militaris

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Cordyceps militaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Cordyceps militaris
-
 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Cordyceps militaris CM01
-
 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?

Organism

Organism UniProt Comment Textmining
Cordyceps militaris G3JF09
-
-
Cordyceps militaris CM01 G3JF09
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase in purine nucleotide metabolism is highly upregulated in the liquid surface culture compared to submerged culture Cordyceps militaris
-
mycelium mycelia formation in the liquid surface culture Cordyceps militaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Cordyceps militaris ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Cordyceps militaris CM01 ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?

Synonyms

Synonyms Comment Organism
CCM_04437 gene name, UniProt Cordyceps militaris
phosphoribosylaminoimidazole-succinocarboxamide synthase
-
 Cordyceps militaris
SAICAR synthase
-
 Cordyceps militaris

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Cordyceps militaris

Expression

Organism Comment Expression
Cordyceps militaris phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase is significantly upregulated in the liquid surface culture compared to submerged culture up

General Information

General Information Comment Organism
metabolism the enzyme is involved in the purine nucleotide metabolism, catalyzing the formation pf a pecursor of cordycepin Cordyceps militaris