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Literature summary for 6.3.2.6 extracted from

  • Nelson, S.W.; Binkowski, D.J.; Honzatko, R.B.; Fromm, H.J.
    Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase (2005), Biochemistry, 44, 766-774.
    View publication on PubMed
Search for more literature for 6.3.2.6

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-(beta,gamma-imido)triphosphate
-
 Escherichia coli
IMP competitive with respect to 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
Maleate competitive with respect to L-Asp Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp rapid equilibrium random ter-ter mechanism Escherichia coli ADP + phosphate + 1-(5'-phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
-
 ?

Synonyms

Synonyms Comment Organism
Phosphoribosylaminoimidazolesuccinocarboxamide synthetase
-
 Escherichia coli
SAICAR synthetase
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.26
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kis, competitive versus ATP Escherichia coli
0.6
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kii, noncompetitive versus L-Asp Escherichia coli
0.6
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kis, noncompetitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
0.7
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kis, noncompetitive versus L-Asp Escherichia coli
4
-
 adenosine 5'-(beta,gamma-imido)triphosphate 37°C, Kii, noncompetitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
7
-
 IMP 37°C, Kis, noncompetitive versus ATP Escherichia coli
7
-
 IMP 37°C, Kis, noncompetitive versus L-Asp Escherichia coli
9
-
 IMP 37°C, Kii, noncompetitive versus ATP Escherichia coli
9.1
-
 IMP 37°C, Kis, competitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
12
-
 Maleate 37°C, Kis, noncompetitive versus ATP Escherichia coli
13
-
 IMP 37°C, Kii, noncompetitive versus L-Asp Escherichia coli
15
-
 Maleate 37°C, Kis, competitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
16
-
 Maleate 37°C, Kis, competitive versus L-Asp Escherichia coli
40
-
 Maleate 37°C, Kii, competitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole Escherichia coli
50
-
 Maleate 37°C, Kii, noncompetitive versus ATP Escherichia coli