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Literature summary for 6.3.2.6 extracted from

  • Urusova, D.V.; Antonyuk, S.V.; Grebenko, A.I.; Lamzin, V.S.; Melik-Adamyan, V.R.
    X-ray diffraction study of the complex of the enzyme SAICAR synthase with substrate analogs (2003), Crystallogr. Rep., 48, 763-767.
No PubMed abstract available
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Crystallization (Commentary)

Crystallization (Comment) Organism
crystals of SAICAR complexed with 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide and succinic acid are grown by hanging drop vapor diffusion at room temperature, mother liquor consists of 24 mg/ml SAICAR, 1 M ammonium sulfate, 100 mM 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide, 100 mM succinic acid and 50 mM Tris-HCl, pH 7.5, crystals diffract to 1.3 A Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Saccharomyces cerevisiae
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 ADP + phosphate + (S)-2-[5-amino1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Saccharomyces cerevisiae ADP + phosphate + (S)-2-[5-amino1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?

Synonyms

Synonyms Comment Organism
SAICAR synthase
-
 Saccharomyces cerevisiae