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Literature summary for 6.3.2.5 extracted from

  • Balibar, C.J.; Hollis-Symynkywicz, M.F.; Tao, J.
    Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa (2011), J. Bacteriol., 193, 3304-3312.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 single gene coaBC encoding a bifunctional protein catalyzing two consecutive steps in the CoA pathway converting 4-phosphopantothenate to 4-phosphopantetheine
-
Pseudomonas aeruginosa
-
 single gene coaBC encoding a bifunctional protein catalyzing two consecutive steps in the CoA pathway converting 4-phosphopantothenate to 4-phosphopantetheine
-

Synonyms

Synonyms Comment Organism
CoaBC
-
 Escherichia coli
CoaBC
-
 Pseudomonas aeruginosa

General Information

General Information Comment Organism
physiological function gene coaBC is essential, but Escherichia coli can effectively metabolize pantethine to bypass the requirement for coaBC Escherichia coli
physiological function gene coaBC is essential. Contrary to Escherichia coli, Pseudomonas aeruginosa cannot metabolize pantethine to bypass the requirement for coaBC Pseudomonas aeruginosa