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Literature summary for 6.3.2.5 extracted from

  • Bosveld, F.; Rana, A.; Lemstra, W.; Kampinga, H.H.; Sibon, O.C.
    Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis (2008), BMC Res. Notes, 1, 75.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.5

Protein Variants

Protein Variants Comment Organism
additional information mutation in dPPCS impair female fecundity and fertility, and disrupts the organization of the somatic and germ line cells, affects F-actin organization and results in abnormal PtdIns(4,5)P2 localization. Improper cell organization coincides with aberrant localization of the membrane molecules Gurken (Grk) and Notch, whose activities are required for specification of the follicle cells that pattern the eggshell. Mutations in dPPCS also induce alterations in scutellar patterning and cause wing vein abnormalities, phenotype, detailed overview Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + (R)-4'-phosphopantothenate + L-cysteine Drosophila melanogaster the enzyme is required for various processes that occur during oogenesis including chorion patterning, e.g. for F-actin remodeling during cytoplasmic dumping, overview CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
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Source Tissue

Source Tissue Comment Organism Textmining
oocyte
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 Drosophila melanogaster
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ovary
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 Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + (R)-4'-phosphopantothenate + L-cysteine
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 Drosophila melanogaster CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?
CTP + (R)-4'-phosphopantothenate + L-cysteine the enzyme is required for various processes that occur during oogenesis including chorion patterning, e.g. for F-actin remodeling during cytoplasmic dumping, overview Drosophila melanogaster CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
phosphopantothenoylcysteine synthetase
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 Drosophila melanogaster
PPCS
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 Drosophila melanogaster