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Literature summary for 6.3.2.42 extracted from

  • Becker, I.; Wang-Eckhardt, L.; Lodder-Gadaczek, J.; Wang, Y.; Gruenewald, A.; Eckhardt, M.
    Mice deficient in the NAAG synthetase II gene Rimkla are impaired in a novel object recognition task (2021), J. Neurochem., 157, 2008-2023.
    View publication on PubMed
Search for more literature for 6.3.2.42

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate Mus musculus
-
 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain stem most abundant Mus musculus
-
hippocampus in hippocampus, the enzyme is detectable in neurons expressing parvalbumin Mus musculus
-
spinal cord most abundant Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
-
 Mus musculus 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?

Subunits

Subunits Comment Organism
? x * about 50000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
NAAG hydrolase glutamate carboxypeptidase II
-
 Mus musculus
NAAG synthetase II
-
 Mus musculus
NAAGS-II
-
 Mus musculus
RIMKLA
-
 Mus musculus

General Information

General Information Comment Organism
malfunction mice deficient in the enzyme gene are impaired in a novel object recognition task Mus musculus
physiological function N-acetyl-L-aspartyl-L-glutamate synthesized by the enzyme is directly involved in the memory consolidation underlying the novel object recognition task Mus musculus