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Literature summary for 6.3.2.42 extracted from

  • Lodder-Gadaczek, J.; Becker, I.; Gieselmann, V.; Wang-Eckhardt, L.; Eckhardt, M.
    N-Acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate (2011), J. Biol. Chem., 286, 16693-16706.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.42

Cloned(Commentary)

Cloned (Comment) Organism
expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells Mus musculus
expressed as FLAG epitope-tagged protein in HEK-293T and CHO-K1 cells. Because hexahistidine-tagged Escherichia coli-expressed enzyme using bacterial expressed protein Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
 x * 42000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate Mus musculus
-
 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?
ATP + N-acetyl-L-aspartate + L-glutamate Mus musculus
-
 ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus Q6PFX8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain stem
-
 Mus musculus
-
central nervous system highest expression levels in the brain stem and spinal cord, almost undetectable in the neocortex Mus musculus
-
cerebellum
-
 Mus musculus
-
cerebellum strong expression is restricted to deep cerebellar nuclei Mus musculus
-
forebrain
-
 Mus musculus
-
kidney
-
 Mus musculus
-
sciatic nerve
-
 Mus musculus
-
spinal cord
-
 Mus musculus
-
spinal cord expression is found in the ventral and dorsal horns of gray matter in laminae III to X, but is low or absent in laminae I and II Mus musculus
-
testis
-
 Mus musculus
-
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate
-
 Mus musculus 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?
2 ATP + N-acetyl-L-aspartate + 2 L-glutamate the enzyme also has the activity of EC 6.3.2.41, N-acetylaspartylglutamate synthase Mus musculus 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?
ATP + N-acetyl-L-aspartate + L-glutamate
-
 Mus musculus ADP + phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
-
 ?

Subunits

Subunits Comment Organism
? x * 42000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
N-acetylaspartylglutamate synthetase II
-
 Mus musculus
N-acetylaspartylglutamylglutamate synthetase
-
 Mus musculus
NAAG synthetase II
-
 Mus musculus
NAAG(2) synthase
-
 Mus musculus
NAAGS-II
-
 Mus musculus
RIMKLA gene name, ambiguous Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus