Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WP79 | cf. EC 6.3.2.31 | - |
Mycobacterium tuberculosis ATCC 25618 | P9WP79 | cf. EC 6.3.2.31 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
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additional information | F420H2 is the preferred substrate for the extension of glutamate chains of F420 by FbiB | Mycobacterium tuberculosis | ? | - |
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additional information | F420H2 is the preferred substrate for the extension of glutamate chains of F420 by FbiB | Mycobacterium tuberculosis ATCC 25618 | ? | - |
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General Information | Comment | Organism |
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physiological function | in vitro, MtbFbiB synthesizes side chains containing up to seven glutamate residues if cofactor F420 is presented to the enzyme in a two-electron reduced state (F420H2). The polyglutamylation process requires the assistance of F420-dependent glucose-6-phosphate dehydrogenase (Fgd) which reduces F420 to F420H2. Starting with F420-0H2, the amino-terminal domain of FbiB may build F420-2H2, which is then transferred to the carboxy-terminal domain for further glutamylation. F420-2H2 modifies the carboxy-terminal domain structurally to accommodate longer glutamyl chains | Mycobacterium tuberculosis |