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Literature summary for 6.3.2.31 extracted from

  • Purwantini, E.; Loganathan, U.; Mukhopadhyay, B.
    Coenzyme F420-dependent glucose-6-phosphate dehydrogenase-coupled polyglutamylation of coenzyme F420 in mycobacteria (2018), J. Bacteriol., 200, e00375 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.31

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WP79 cf. EC 6.3.2.34
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Mycobacterium tuberculosis ATCC 25618 P9WP79 cf. EC 6.3.2.34
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information F420H2 is the preferred substrate for the extension of glutamate chains of F420 by FbiB Mycobacterium tuberculosis ?
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additional information F420H2 is the preferred substrate for the extension of glutamate chains of F420 by FbiB Mycobacterium tuberculosis ATCC 25618 ?
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General Information

General Information Comment Organism
physiological function in vitro, MtbFbiB synthesizes side chains containing up to seven glutamate residues if cofactor F420 is presented to the enzyme in a two-electron reduced state (F420H2). The polyglutamylation process requires the assistance of F420-dependent glucose-6-phosphate dehydrogenase (Fgd) which reduces F420 to F420H2. Starting with F420-0H2, the amino-terminal domain of FbiB may build F420-2H2, which is then transferred to the carboxy-terminal domain for further glutamylation. F420-2H2 modifies the carboxy-terminal domain structurally to accommodate longer glutamyl chains Mycobacterium tuberculosis