Literature summary for 6.3.2.3 extracted from

Yang, H.; Zeng, Y.; Lee, T.D.; Yang, Y.; Ou, X.; Chen, L.; Haque, M.; Rippe, R.; Lu, S.C.
Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone (2002), J. Biol. Chem., 277, 35232-35239.

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Activating Compound

Activating Compound	Comment	Organism	Structure
activator protein 1	i.e. AP-1, mediates the induction of enzyme expression by tert-butylhydroquinone, binds to the enzyme promotor, antagonisted by c-jun, a dominant negative which is also produced in enhanced levels after treatment with tert-butylhydroquinone	Rattus norvegicus
tert-butylhydroquinone	regulatory role, activator protein 1 AP-1-mediated induction of enzyme expression, 35fold increase in activity in recombinant H4IIE cells, induction of c-jun formation, which is a negative regulatory protein blocking the binding of activatot protein 1 to the promotor	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
cloning of the 2.2 kb 5'-flanking region, DNA sequence determination and analysis, promotor determination, determination of positive and negative regulation regions, e.g. NF1 repressor for induction of enzyme expression by tert-butylhydroquinone, expression in H4IIE cells, ATCC CRL-1548, via transformation by recombinant adenovirus vector	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
c-jun	negative regulation of enzyme expression by blocking the binding of AP-1 to the promotor	Rattus norvegicus
tert-butylhydroquinone	regulatory role, activator protein 1 AP-1-mediated induction of enzyme expression, 35fold increase in activity in recombinant H4IIE cells, induction of c-jun formation, which is a negative regulatory protein blocking the binding of activator protein 1 to the promotor	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + gamma-L-Glu-L-Cys + Gly	Rattus norvegicus	-	ADP + phosphate + glutathione	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	AF333982	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + gamma-L-Glu-L-Cys + Gly	-	Rattus norvegicus	ADP + phosphate + glutathione	-	?

Synonyms

Synonyms	Comment	Organism
Glutathione synthetase	-	Rattus norvegicus
GS	-	Rattus norvegicus

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Release 2023.1 (January 2023)