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Literature summary for 6.3.2.3 extracted from
- Inducers of gamma-glutamylcysteine synthetase and their effects on glutathione synthetase expression (2000), Biochim. Biophys. Acta, 1493, 48-55.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| buthionine sulfoximine | increase in enzyme expression in hepatocytes by 2.55fold after 18 h | Rattus norvegicus |  |
| diethyl maleate | increase in enzyme expression in hepatocytes 1.6fold | Rattus norvegicus | |
| additional information | enzyme expression in not affected by insulin and hydrocortisone treatment or by ethanol-feeding, a partial hepatectomy lead to increase in enzyme expression 2.7fold after 12 h | Rattus norvegicus | |
| tert-butylhydroquinone | increase in enzyme expression in hepatocytes 1.7fold | Rattus norvegicus | |
| Thioacetamide | increases the enzyme expression and activity in Chang cells by 50% at 6.66 mM | Homo sapiens | |
| Thioacetamide | increases the enzyme expression and activity in hepatocyte cell culture and in liver 5fold in vivo | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme expression in not affected by insulin and hydrocortisone treatment or by ethanol-feeding | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + gamma-L-Glu-L-Cys + Gly | Homo sapiens | - |
ADP + phosphate + glutathione | - |
? | |
| ATP + gamma-L-Glu-L-Cys + Gly | Rattus norvegicus | - |
ADP + phosphate + glutathione | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | Chang cell | Homo sapiens | - |
| cell culture | hepatocyte | Rattus norvegicus | - |
| Chang cell | ATCC CCL-13, cell culture | Homo sapiens | - |
| hepatocyte | cell culture | Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + gamma-L-Glu-L-Cys + Gly | - |
Homo sapiens | ADP + phosphate + glutathione | - |
? | |
| ATP + gamma-L-Glu-L-Cys + Gly | - |
Rattus norvegicus | ADP + phosphate + glutathione | - |
? | |
| ATP + gamma-L-Glu-L-Cys + Gly | in presence of dithiothreitol | Rattus norvegicus | ADP + phosphate + glutathione | - |
? | |
| ATP + gamma-L-Glu-L-Cys + Gly | inpresence of dithiothreitol | Homo sapiens | ADP + phosphate + glutathione | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Glutathione synthetase | - |
Homo sapiens |
| Glutathione synthetase | - |
Rattus norvegicus |
| GS | - |
Homo sapiens |
| GS | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | - |
assay at | Homo sapiens |
| 7.3 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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