Cloned (Comment) | Organism |
---|---|
genes GCLC and GCLM, quantitative RT-PCR expression analysis in biopsy samples from head and neck squamous cell carcinoma tissues and adjacent normal tissues | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | GCLM expression | Homo sapiens | 5737 | - |
additional information | the expression of subunit GCLM is co-localized with the expression of the proliferation marker Ki?67 | Homo sapiens | - |
- |
nucleus | GCLM expression | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P48506 AND P48507 | genes GCLC and GCLM encoding catalytic and modifier subunits | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
head and neck squamous carcinoma cell | subunit GCLM, but not subunit GCLC, expression is significantly increased in tumor samples, compared with normal mucosa, both at the mRNA and protein level | Homo sapiens | - |
larynx | - |
Homo sapiens | - |
mouth | - |
Homo sapiens | - |
oropharynx | - |
Homo sapiens | - |
tongue | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GCL | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme catalyzes the first rate-limiting step in the biosynthesis of glutathione. Glutathione (GSH) is the keystone of the cellular response toward oxidative stress. Elevated GSH content correlates with increased resistance to chemotherapy and radiotherapy of head and neck (HN) tumors. Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma. The localization of GSH synthesis contributes to the protection against oxidative stress within hotspots of cell proliferation. The expression of glutamate-cysteine ligase (GCL) accounts for the increased GSH availability observed in head and neck squamous cell carcinoma (SCC). No role of the NRF2 and NF?kappaB signaling pathways in GCLM activation | Homo sapiens |