Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.2.2 extracted from

  • Dequanter, D.; van de Velde, M.; Bar, I.; Nuyens, V.; Rousseau, A.; Nagy, N.; Vanhamme, L.; Vanhaeverbeek, M.; Brohee, D.; Delree, P.; Boudjeltia, K.; Lothaire, P.; Uzureau, P.
    Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma (2016), Oncol. Lett., 11, 3660-3668 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
genes GCLC and GCLM, quantitative RT-PCR expression analysis in biopsy samples from head and neck squamous cell carcinoma tissues and adjacent normal tissues Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm GCLM expression Homo sapiens 5737
-
additional information the expression of subunit GCLM is co-localized with the expression of the proliferation marker Ki?67 Homo sapiens
-
-
nucleus GCLM expression Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P48506 AND P48507 genes GCLC and GCLM encoding catalytic and modifier subunits
-

Source Tissue

Source Tissue Comment Organism Textmining
head and neck squamous carcinoma cell subunit GCLM, but not subunit GCLC, expression is significantly increased in tumor samples, compared with normal mucosa, both at the mRNA and protein level Homo sapiens
-
larynx
-
Homo sapiens
-
mouth
-
Homo sapiens
-
oropharynx
-
Homo sapiens
-
tongue
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
GCL
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme catalyzes the first rate-limiting step in the biosynthesis of glutathione. Glutathione (GSH) is the keystone of the cellular response toward oxidative stress. Elevated GSH content correlates with increased resistance to chemotherapy and radiotherapy of head and neck (HN) tumors. Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma. The localization of GSH synthesis contributes to the protection against oxidative stress within hotspots of cell proliferation. The expression of glutamate-cysteine ligase (GCL) accounts for the increased GSH availability observed in head and neck squamous cell carcinoma (SCC). No role of the NRF2 and NF?kappaB signaling path­ways in GCLM activation Homo sapiens