Literature summary for 6.3.2.2 extracted from

Nichenametla, S.N.; Ellison, I.; Calcagnotto, A.; Lazarus, P.; Muscat, J.E.; Richie, J.P.
Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of gamma-glutamylcysteine ligase (2008), Free Radic. Biol. Med., 45, 645-650.

Search for more literature for 6.3.2.2

Cloned(Commentary)

Cloned (Comment)	Organism
gene GCLC, DNA and amino acid sequence determination and analysis, genotyping	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	a GAG-repeat polymorphism in the 5'-UTR of the gene coding for the catalytic subunit, GCLC, is associated with altered GSH levels in vitro and in vivo	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-glutamate + L-cysteine	Homo sapiens	rate-limiting enzyme in glutathione synthesis, a mutation in the catalytic subunit gene 5'-UTR leads to reduced enzyme activity	ADP + phosphate + gamma-L-glutamyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	correlation between enzyme activity and genotype in black and white individuals, overview	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-glutamate + L-cysteine	-	Homo sapiens	ADP + phosphate + gamma-L-glutamyl-L-cysteine	-	?
ATP + L-glutamate + L-cysteine	rate-limiting enzyme in glutathione synthesis, a mutation in the catalytic subunit gene 5'-UTR leads to reduced enzyme activity	Homo sapiens	ADP + phosphate + gamma-L-glutamyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
gamma-glutamylcysteine ligase	-	Homo sapiens
GCL	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)