Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | both GCLC gene expression and total GSH levels increase 4 and 1.5fold, respectively, in response to hyperthermal stress, overview | Exaiptasia diaphana |
Cloned (Comment) | Organism |
---|---|
gene gclC encoding the catalytic subunit, DNA and amino acid sequence determination and analysis, quantitative expression analysis | Exaiptasia diaphana |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Exaiptasia diaphana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | Exaiptasia diaphana | rate-limiting step in glutathione biosynthesis | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | Exaiptasia diaphana | hyperthermal stress triggers adaptive increases in intracellular GSH biosynthesis in cnidarians as a protective response to oxidative/nitrosative stress, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Exaiptasia diaphana | B2ZG39 | symbiotic sea anemone, genes gclC and gclM encoding the catalytic and the modifier subunits of the enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | - |
Exaiptasia diaphana | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
ATP + L-glutamate + L-cysteine | rate-limiting step in glutathione biosynthesis | Exaiptasia diaphana | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | hyperthermal stress triggers adaptive increases in intracellular GSH biosynthesis in cnidarians as a protective response to oxidative/nitrosative stress, overview | Exaiptasia diaphana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCL | - |
Exaiptasia diaphana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Exaiptasia diaphana |