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Literature summary for 6.3.2.2 extracted from

  • Siedlinski, M.; Postma, D.S.; van Diemen, C.C.; Blokstra, A.; Smit, H.A.; Boezen, H.M.
    Lung function loss, smoking, vitamin C intake, and polymorphisms of the glutamate-cysteine ligase genes (2008), Am. J. Respir. Crit. Care Med., 178, 13-19.
    View publication on PubMed
Search for more literature for 6.3.2.2

Cloned(Commentary)

Cloned (Comment) Organism
genes gclc and gclm, genotyping, analysis of correlation between genotype and smoking effects, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information GCLC polymorphisms are associated with lower lung function levels causing lung disease, especially in association with oxidative stress due to smoking Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + L-cysteine Homo sapiens the enzyme acts endogenously as an antioxidant and is involved in glutathione biosynthesis ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
additional information Homo sapiens GCLC polymorphisms are associated with lower lung function levels causing lung disease, especially in association with oxidative stress due to smoking ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene gclC and gclM encoding the two subunits of the enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + L-cysteine
-
 Homo sapiens ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
ATP + L-glutamate + L-cysteine the enzyme acts endogenously as an antioxidant and is involved in glutathione biosynthesis Homo sapiens ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
additional information GCLC polymorphisms are associated with lower lung function levels causing lung disease, especially in association with oxidative stress due to smoking Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer heterodimer consisting of subunits GCLC and GCLM Homo sapiens

Synonyms

Synonyms Comment Organism
GCL
-
 Homo sapiens
glutamate-cysteine ligase
-
 Homo sapiens