Cloned (Comment) | Organism |
---|---|
genes gclc and gclm, genotyping, analysis of correlation between genotype and smoking effects, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | GCLC polymorphisms are associated with lower lung function levels causing lung disease, especially in association with oxidative stress due to smoking | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | Homo sapiens | the enzyme acts endogenously as an antioxidant and is involved in glutathione biosynthesis | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | Homo sapiens | GCLC polymorphisms are associated with lower lung function levels causing lung disease, especially in association with oxidative stress due to smoking | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene gclC and gclM encoding the two subunits of the enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | - |
Homo sapiens | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
ATP + L-glutamate + L-cysteine | the enzyme acts endogenously as an antioxidant and is involved in glutathione biosynthesis | Homo sapiens | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | GCLC polymorphisms are associated with lower lung function levels causing lung disease, especially in association with oxidative stress due to smoking | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | heterodimer consisting of subunits GCLC and GCLM | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
GCL | - |
Homo sapiens |
glutamate-cysteine ligase | - |
Homo sapiens |