Literature summary for 6.3.2.2 extracted from

Orr, W.C.; Radyuk, S.N.; Prabhudesai, L.; Toroser, D.; Benes, J.J.; Luchak, J.M.; Mockett, R.J.; Rebrin, I.; Hubbard, J.G.; Sohal, R.S.
Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster (2005), J. Biol. Chem., 280, 37331-37338.

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Cloned(Commentary)

Cloned (Comment)	Organism
the GAL4-UAS binary transgenic system is used to generate flies overexpressing either the catalytic (GCLc) or modulatory (GCLm) subunit of this enzyme, in a global or neuronally targeted pattern	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enhancement of the glutathione biosynthetic capability, particularly in neuronal tissues, can extend the life span of flies	Drosophila melanogaster	?	-	?

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Release 2023.1 (January 2023)