Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GSH | noncompetitive versus L-glutamate or ATP | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.22 | - |
L-cysteine | 37°C, pH 7.2, holoenzyme | Mus musculus | |
0.27 | - |
L-cysteine | 37°C, pH 7.2, catalytic subunit GCLC | Mus musculus | |
0.48 | - |
L-glutamate | 37°C, pH 7.2, holoenzyme | Mus musculus | |
0.87 | - |
ATP | 37°C, pH 7.2, holoenzyme | Mus musculus | |
1.6 | - |
L-glutamate | 37°C, pH 7.2, catalytic subunit GCLC | Mus musculus | |
5 | - |
ATP | 37°C, pH 7.2, catalytic subunit GCLC | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | rate-limiting enzyme in GSH biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
additional information | in most tissues the modifier subunit GCLM is limiting, suggesting that an increase in GCLM alone would increase gamma-glutamylcysteine synthesis | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | - |
Mus musculus | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | rate-limiting enzyme in GSH biosynthesis | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | reaction is catalyzed by the catalytic subunit GCLC or by the holoenzyme (GCLholo), which comprises GCLC and the modifier subunit GCLM. GCLM decreases the Km for ATP by about 6fold and decreases the Km-value for glutamate and increases the Ki-value for feedback inhibition by GSH. GCLM increases by 4.4fold the turnover number for gamma-glutamylcysteine synthesis | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
GCL | - |
Mus musculus |
glutamate cysteine ligase | - |
Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.9 | - |
L-glutamate | 37°C, pH 7.2, catalytic subunit GCLC | Mus musculus | |
1.9 | - |
L-cysteine | 37°C, pH 7.2, catalytic subunit GCLC | Mus musculus | |
1.9 | - |
ATP | 37°C, pH 7.2,catalytic subunit GCLC | Mus musculus | |
8.2 | - |
ATP | 37°C, pH 7.2, holoenzyme | Mus musculus | |
8.2 | - |
L-glutamate | 37°C, pH 7.2, holoenzyme | Mus musculus | |
8.2 | - |
L-cysteine | 37°C, pH 7.2, holoenzyme | Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
GSH | Kis, 37°C, pH 7.2, catalytic subunit GCLC, versus L-glutamate | Mus musculus | |
0.4 | - |
GSH | Kii, 37°C, pH 7.2, catalytic subunit GCLC, versus ATP | Mus musculus | |
0.8 | - |
GSH | Kii, 37°C, pH 7.2, catalytic subunit GCLC, versus L-glutamate | Mus musculus | |
0.8 | - |
GSH | Kis, 37°C, pH 7.2, holoenzyme, versus L-glutamate | Mus musculus | |
1.3 | - |
GSH | Kis, 37°C, pH 7.2, catalytic subunit GCLC, versus ATP | Mus musculus | |
3.1 | - |
GSH | Kii, 37°C, pH 7.2, holoenzyme, versus L-glutamate | Mus musculus | |
3.9 | - |
GSH | Kii, 37°C, pH 7.2, holoenzyme, versus ATP | Mus musculus | |
6.5 | - |
GSH | Kis, 37°C, pH 7.2, holoenzyme, versus ATP | Mus musculus |