Literature summary for 6.3.2.2 extracted from

Walsh, A.C.; Feulner, J.A.; Reilly, A.
Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel (2001), Toxicol. Sci., 61, 218-223.

Cloned(Commentary)

Cloned (Comment)	Organism
DNA sequence determination and analysis, heterodimer of a catalytic subunit and a regulatory subunit, encoded by 2 genes: GLCLC for the catalytic subunit, and GLCLR for the regulatory subunit, GLCLC polymorphism and existence of 5 alleles as defined by the trinucleotide repeat, which exhibits a range of 4 to 10 uninterrupted repeat, genotyping for the repeat of 60 tumor cancer cell lines, overview	Homo sapiens

Cloned (Comment)

Organism

DNA sequence determination and analysis, heterodimer of a catalytic subunit and a regulatory subunit, encoded by 2 genes: GLCLC for the catalytic subunit, and GLCLR for the regulatory subunit, GLCLC polymorphism and existence of 5 alleles as defined by the trinucleotide repeat, which exhibits a range of 4 to 10 uninterrupted repeat, genotyping for the repeat of 60 tumor cancer cell lines, overview

Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the genotype of GLCLC is associated with drug sensitivity or resistance, respectively, sensitivity of different genotypes to diverse drugs, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-Glu + L-Cys	Homo sapiens	first and rate limiting step in glutathione biosynthesis	ADP + phosphate + gamma-L-Glu-L-Cys	-	?
additional information	Homo sapiens	the genotype of GLCLC is associated with drug sensitivity or resistance, respectively	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	genotyping of 60 tumor cell lines from diverse source tissues for the GLCLC trinuleotide repeat	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
ATP + L-Glu + L-Cys	-	Homo sapiens	ADP + phosphate + gamma-L-Glu-L-Cys	-	?
ATP + L-Glu + L-Cys	first and rate limiting step in glutathione biosynthesis	Homo sapiens	ADP + phosphate + gamma-L-Glu-L-Cys	-	?
additional information	the genotype of GLCLC is associated with drug sensitivity or resistance, respectively	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
dimer	heterodimer of a catalytic subunit and a regulatory subunit, encoded by 2 genes	Homo sapiens

Synonyms

Synonyms	Comment	Organism
GCL	-	Homo sapiens
GLCLC	-	Homo sapiens
GLCLR	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens