Literature summary for 6.3.2.2 extracted from

Gullner, G.; Komives, T.; Rennenberg, H.
Enhanced tolerance of transgenic poplar plants overexpressing gamma-glutamylcysteine synthetase towards chloroacetanilide herbicides (2001), J. Exp. Bot., 52, 971-979.

Search for more literature for 6.3.2.2

Activating Compound

Activating Compound	Comment	Organism	Structure
2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)-acetamide	i.e. metolachlor, a herbicide that decreases the plant growth and and biomass, induction of enzyme expression, enhanced enzyme activity leads to enhanced detoxification activity	Populus tremula x Populus alba
2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)-acetamide	i.e. acetochlor, a herbicide that decreases the plant growth and and biomass, induction of enzyme expression, enhanced enzyme activity leads to enhanced detoxification activity	Populus tremula x Populus alba

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of transgenic poplar plants expressing the bacterial enzyme in the cytosol and chloroplasts, transgenic plants show increased enzyme expression and induction, as well as increased detoxification activity and less phytootxic effects by the herbcides, overview	Populus tremula x Populus alba

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-Glu + L-Cys	Populus tremula x Populus alba	the enzyme is involved in the biosynthesis of GSH, which is used for detoxification of herbicides by the plant	ADP + phosphate + gamma-L-Glu-L-Cys	-	?

Organism

Organism	UniProt	Comment	Textmining
Populus tremula x Populus alba	-	hybrid, INRA-clone Nr. 717-1-B4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Populus tremula x Populus alba	-
root	-	Populus tremula x Populus alba	-
shoot	-	Populus tremula x Populus alba	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-Glu + L-Cys	-	Populus tremula x Populus alba	ADP + phosphate + gamma-L-Glu-L-Cys	-	?
ATP + L-Glu + L-Cys	the enzyme is involved in the biosynthesis of GSH, which is used for detoxification of herbicides by the plant	Populus tremula x Populus alba	ADP + phosphate + gamma-L-Glu-L-Cys	-	?

Synonyms

Synonyms	Comment	Organism
gamma-Glutamylcysteine synthetase	-	Populus tremula x Populus alba

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Populus tremula x Populus alba

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Release 2023.1 (January 2023)