Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apigenin | nearly 2fold induction of the heavy subunit gene promotor and heavy subunit expression | Homo sapiens | |
kaempferol | 2fold induction of the heavy subunit gene promotor and heavy subunit expression | Homo sapiens | |
additional information | no increase in gene promotor activity by myricetin and sugar conjugates of quercetin, quercetin-3-glucoside and quercetin-3-rhamnoglucoside | Homo sapiens | |
onion extract | containing flavonoids, which increase the expression of both subunits of the enzyme in COS-1 cells | Homo sapiens | |
quercetin | 3fold induction of the heavy subunit gene promotor and heavy subunit expression, best at 0.05 mM, induction even of a distal part of the promotor sequence containing only 2 antioxidant-response/electrophile-response elements, i.e. ARE/EpRE | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of a construct consisting of 3.8 kb of the enzyme's heavy subunit gene promotor in front of luciferase as well as a fragment of the 5'-flanking sequence, transient expression in COS-1 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Glu + L-Cys | - |
Homo sapiens | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | heavy and light subunit | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
gamma-glutaminylcysteine synthetase | - |
Homo sapiens |
GCS | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |