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Literature summary for 6.3.2.2 extracted from
- The coffee components kahweol and cafestol induce g-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat (2002), Arch. Toxicol., 75, 685-694.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cafestol | coffee component, induction of the enzyme in vivo, especially in the liver up to 2.4fold, increase in expression of both enzyme subunits | Rattus norvegicus |  |
| kahweol | coffee component, induction of the enzyme in vivo, especially in the liver up to 2.4fold, increase in expression of both enzyme subunits | Rattus norvegicus | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme may be a key factor in the chemopreventive potential of coffee components kahweol and cafestol | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Glu + L-Cys | Rattus norvegicus | rate-limiting step of the chemoprotective glutathione synthesis | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male F344 rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Glu + L-Cys | - |
Rattus norvegicus | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
| ATP + L-Glu + L-Cys | rate-limiting step of the chemoprotective glutathione synthesis | Rattus norvegicus | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | heavy and light subunit | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| gamma-Glutamylcysteine synthetase | - |
Rattus norvegicus |
| GCS | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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