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Literature summary for 6.3.2.17 extracted from

  • Li, L.; Hill-Skinner, S.; Liu, S.; Beuchle, D.; Tang, H.M.; Yeh, C.T.; Nettleton, D.; Schnable, P.S.
    The maize brown midrib4 (bm4) gene encodes a functional folylpolyglutamate synthase (2015), Plant J., 81, 493-504 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.17

Cloned(Commentary)

Cloned (Comment) Organism
gene GRMZM2G393334, DNA and amino acid sequence determination and analysis, expression of the enzyme in FPGS-deficient met7 yeast rescues the yeast mutant phenotype Zea mays

Protein Variants

Protein Variants Comment Organism
additional information at least four of 10 Mu-induced bm4 mutant alleles contain a Mu insertion in the FPGS GRMZM2G393334 gene, PCR-based sequencing of Mu-tagging alleles, the enzyme expression is reduced in the brown midrib4 (bm4) mutant, bm4 encodes a functional FPGS, sequence analysis and quantitative RT-PCR expression analysis of bm4-Mu alleles Zea mays

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Zea mays

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate Zea mays
-
 ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Zea mays K7VM84
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
-
 Zea mays ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
-
 ?

Synonyms

Synonyms Comment Organism
100194131
-
 Zea mays
Folylpolyglutamate synthase
-
 Zea mays
FPGS
-
 Zea mays
GRMZM2G393334
-
 Zea mays

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Zea mays

General Information

General Information Comment Organism
malfunction the enzyme expression is reduced in the brown midrib4 (bm4) mutant, the mutation of gene bm4 affects the accumulation and composition of lignin in maize, phenotype, overview. bm4 mutants exhibit a modest decrease in lignin concentration and an overall increase in the S:G lignin ratio relative to wild-type. At least four of 10 Mu-induced bm4 mutant alleles contain a Mu insertion in the FPGS GRMZM2G393334 gene Zea mays
metabolism folylpolyglutamate synthase (FPGS) functions in one-carbon (C1) metabolism and in lignin biosynthesis, lignin biosynthesispathway overview Zea mays
physiological function folylpolyglutamate synthase (FPGS) functions in one-carbon (C1) metabolism to polyglutamylate substrates of folate-dependent enzymes. Role for FPGS in lignin biosynthesis Zea mays