Cloned (Comment) | Organism |
---|---|
gene fpgs, determination of genotypes and mRNA expression levels in 190 female and male unrelated healthy Japanese people, quantitative real-time PCR enzyme expression analysis reveals significant differences in sex-specific mRNA expression, detailed overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate | Homo sapiens | - |
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q05932 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | quantitative real-time PCR enzyme expression analysis reveals significant differences in sex-specific mRNA expression, detailed overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate | - |
Homo sapiens | ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
folypolyformyl glutamate synthase | - |
Homo sapiens |
FPGS | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | reduced folate carrier-1 (RFC-1), folypolyformyl glutamate synthase (FPGS), and gamma-glutamyl hydrolase (GGH) are important transporters and enzymes that convert methotrexate (MTX) in the body. Significant differences between men and women are observed in RFC-1, FPGS, and GGH mRNA expression in the Japanese population. The mRNA expression of FPGS and GGH is greater in women than that in men, but the expression of RFC-1 is less in the former than the latter. The relationship between genetic polymorphisms and mRNA expression including sex differences might contribute to the variation in the efficacy/toxicity of MTX in patients with rheumatoid arthritis | Homo sapiens |