Application | Comment | Organism |
---|---|---|
medicine | target for antimalarial therapy | Plasmodium falciparum |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli BL21 cells | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]phenyl)(hydroxy)phosphoryl]methyl]pentanedioic acid | - |
Plasmodium falciparum | |
2-[[[(3S)-3-[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]benzoyl)amino]-3-carboxypropyl](hydroxy)phosphoryl]methyl]pentanedioic acid | - |
Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00096 | - |
5,6,7,8-tetrahydrofolate | - |
Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5,6,7,8-tetrahydrofolate + L-glutamate | - |
Plasmodium falciparum | ADP + phosphate + 5,6,7,8-tetrahydrofolyl-Glu | - |
? | |
ATP + L-glutamate + tetrahydrofolate-Glu | assay at pH 10, 37°C | Plasmodium falciparum | ADP + phosphate + tetrahydrofolyl-Glu2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
folypolyglutamate synthase | - |
Plasmodium falciparum |
FPGS | - |
Plasmodium falciparum |
PfDHFS-FPGS | bifunctional protein together with dihydrofolate synthase, EC 6.3.2.12 | Plasmodium falciparum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Plasmodium falciparum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10 | - |
assay at | Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000091 | - |
2-[[[(3S)-3-[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]benzoyl)amino]-3-carboxypropyl](hydroxy)phosphoryl]methyl]pentanedioic acid | - |
Plasmodium falciparum | |
0.00063 | - |
2-[[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]phenyl)(hydroxy)phosphoryl]methyl]pentanedioic acid | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00039 | - |
- |
Plasmodium falciparum | 2-[[[(3S)-3-[(4-[[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino]benzoyl)amino]-3-carboxypropyl](hydroxy)phosphoryl]methyl]pentanedioic acid |
Organism | Comment | Expression |
---|---|---|
Plasmodium falciparum | expressed as single bifunctional protein with dihydrofolate synthase, EC 6.3.2.12 | additional information |