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Literature summary for 6.3.2.17 extracted from

  • Kwon, Y.K.; Lu, W.; Melamud, E.; Khanam, N.; Bognar, A.; Rabinowitz, J.D.
    A domino effect in antifolate drug action in Escherichia coli (2008), Nat. Chem. Biol., 4, 602-608.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
dihydrofolate treatment of cells with trimethoprim leads to inhibition due to accumulation of dihydrofolate through the inhibition of dihydrofolate reductase. Therefore falling dihydrofolate reductase activity leads to falling folylpolyglutamate synthase activity in a domino-like cascade Escherichia coli
trimethoprim treatment of cells leads to inhibition due to accumulation of dihydrofolate through the inhibition of dihydrofolate reductase. Therefore falling dihydrofolate reductase activity leads to falling folylpolyglutamate synthase activity in a domino-like cascade Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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