Crystallization (Comment) | Organism |
---|---|
computational docking of inhibitors to crystal structure. Uracil recognition site is a probable binding site for quinolone inhibitors | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl-2-[(4Z)-tetradec-4-en-1-yl]quinolin-4(1H)-one | inhibitory to enzyme and growth inhibitor of Mycobacterium tuberculosis and rapid-growing mycobacteria | Mycobacterium tuberculosis | |
1-methyl-2-[(5Z)-tetradec-5-en-1-yl]quinolin-4(1H)-one | inhibitory to enzyme and growth inhibitor of Mycobacterium tuberculosis and rapid-growing mycobacteria | Mycobacterium tuberculosis | |
2-[(1E)-dec-1-en-1-yl]-1-methylquinolin-4(1H)-one | inhibitory to enzyme and growth inhibitor of Mycobacterium tuberculosis and rapid-growing mycobacteria | Mycobacterium tuberculosis | |
2-[(1E)-dodec-1-en-1-yl]-1-methylquinolin-4(1H)-one | inhibitory to enzyme and growth inhibitor of Mycobacterium tuberculosis and rapid-growing mycobacteria | Mycobacterium tuberculosis | |
2-[(1E)-tridec-1-en-1-yl]-1-methylquinolin-4(1H)-one | inhibitory to enzyme and growth inhibitor of Mycobacterium tuberculosis and rapid-growing mycobacteria | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + ATP + meso-diaminopimelic acid | - |
Mycobacterium tuberculosis | ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-diaminopimelic acid | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.036 | - |
phosphate-based method, pH 8.5, 37°C | Mycobacterium tuberculosis | 1-methyl-2-[(5Z)-tetradec-5-en-1-yl]quinolin-4(1H)-one | |
0.052 | - |
phosphate-based method, pH 8.5, 37°C | Mycobacterium tuberculosis | 1-methyl-2-[(4Z)-tetradec-4-en-1-yl]quinolin-4(1H)-one | |
0.052 | - |
phosphate-based method, pH 8.5, 37°C | Mycobacterium tuberculosis | 2-[(1E)-tridec-1-en-1-yl]-1-methylquinolin-4(1H)-one | |
0.07 | - |
phosphate-based method, pH 8.5, 37°C | Mycobacterium tuberculosis | 2-[(1E)-dec-1-en-1-yl]-1-methylquinolin-4(1H)-one | |
0.072 | - |
phosphate-based method, pH 8.5, 37°C | Mycobacterium tuberculosis | 2-[(1E)-dodec-1-en-1-yl]-1-methylquinolin-4(1H)-one | |
0.095 | - |
HPLC method, pH 8.5, 37°C | Mycobacterium tuberculosis | 1-methyl-2-[(5Z)-tetradec-5-en-1-yl]quinolin-4(1H)-one | |
0.14 | - |
HPLC method, pH 8.5, 37°C | Mycobacterium tuberculosis | 2-[(1E)-tridec-1-en-1-yl]-1-methylquinolin-4(1H)-one | |
0.159 | - |
HPLC method, pH 8.5, 37°C | Mycobacterium tuberculosis | 1-methyl-2-[(4Z)-tetradec-4-en-1-yl]quinolin-4(1H)-one | |
0.187 | - |
HPLC method, pH 8.5, 37°C | Mycobacterium tuberculosis | 2-[(1E)-dodec-1-en-1-yl]-1-methylquinolin-4(1H)-one | |
0.207 | - |
HPLC method, pH 8.5, 37°C | Mycobacterium tuberculosis | 2-[(1E)-dec-1-en-1-yl]-1-methylquinolin-4(1H)-one |