Cloned (Comment) | Organism |
---|---|
gene folC, DNA and amino acid sequence determination and analysis, genetic structure and sequence comparisons, genotyping of 254 clinical isolates, phylogenetic analysis | Mycobacterium tuberculosis |
Protein Variants | Comment | Organism |
---|---|---|
A132E | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
A171A | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
A420V | naturally occuring mutation in enzyme FolC in clinical isolates of both drug-resistant and drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
A457V | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
D111A | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
D135A | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
D324G | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
D384A | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
E153A | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
E153G | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
E40G | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
E40K | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
E434Q | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
F461F | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
G112S | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
G284G | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
G422G | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
I43A | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
I43F | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
I43S | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
I43T | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
I43V | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
additional information | phylogenetic and structural significance of mutations in gene folC in drug-resistant Mycobacterium tuberculosis, overview. Genotyping of 254 clinical isolates. Enzyme residues E40, I43, S150, and E153 are the most frequently affected amino acid residues in resistant isolates with mutant enzymes, distribution of mutations in the genome-based phylogenetic tree, overview. Mutations at E40, I43, and S150 can alter the structure of the FolC putative binding pocket, causing the PAS derivative to bind outside of the then deformed pocket | Mycobacterium tuberculosis |
P21L | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
P356L | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
P8P | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
P9P | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
R268R | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
R410W | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
R49G | naturally occuring mutation in enzyme FolC in clinical isolates of drug-susceptible Mycobacterium tuberculosis | Mycobacterium tuberculosis |
S150G | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
S335I | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
V256A | naturally occuring mutation in enzyme FolC in clinical isolates of drug-resistant Mycobacterium tuberculosis | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | I6Y0R5 | - |
- |
Mycobacterium tuberculosis ATCC 25618 / H37Rv | I6Y0R5 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
FolC | - |
Mycobacterium tuberculosis |
LH57_13380 | gene name, UniProt | Mycobacterium tuberculosis |
Rv2447c | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations at residues E40, I43, and S150 can alter the structure of FolC's putative binding pocket, causing the PAS derivative to bind outside of the then deformed pocket | Mycobacterium tuberculosis |
additional information | homology modeling of wild-type and mutated FolC, docking study using hydroxydihydropteroate, the metabolic derivative of para-aminosalicylic acid (PAS), to evaluate the binding affinity changes. Para-aminosalicylic acid (PAS) is an example of an anti-tuberculosis agent that blocks the folate pathway in Mycobacterium tuberculosis | Mycobacterium tuberculosis |