BRENDA - Enzyme Database show
show all sequences of 6.3.2.11

The effect of various agents in vitro on homocarnosine-carnosine synthetase from rat brain

Ng, R.H.; Marshall, F.D.; Experientia 32, 839-841 (1976)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
chlorpromazine
0.1 mM stimulates, 1 mM inhibits 45%
Rattus norvegicus
General Stability
General Stability
Organism
dithiothreitol stabilizes
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
alpha-Methyl-dopa
-
Rattus norvegicus
Ca2+
-
Rattus norvegicus
Cd2+
-
Rattus norvegicus
chlorpromazine
0.1 mM stimulates, 1 mM inhibits 45%
Rattus norvegicus
Cu2+
-
Rattus norvegicus
Hg2+
-
Rattus norvegicus
iodoacetamide
-
Rattus norvegicus
Li+
-
Rattus norvegicus
Ni2+
-
Rattus norvegicus
norepinephrine
-
Rattus norvegicus
PCMB
-
Rattus norvegicus
phosphate
-
Rattus norvegicus
Zn2+
-
Rattus norvegicus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + L-His + beta-Ala
-
996
Rattus norvegicus
ADP + phosphate + carnosine
-
996
Rattus norvegicus
-
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
chlorpromazine
0.1 mM stimulates, 1 mM inhibits 45%
Rattus norvegicus
General Stability (protein specific)
General Stability
Organism
dithiothreitol stabilizes
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
alpha-Methyl-dopa
-
Rattus norvegicus
Ca2+
-
Rattus norvegicus
Cd2+
-
Rattus norvegicus
chlorpromazine
0.1 mM stimulates, 1 mM inhibits 45%
Rattus norvegicus
Cu2+
-
Rattus norvegicus
Hg2+
-
Rattus norvegicus
iodoacetamide
-
Rattus norvegicus
Li+
-
Rattus norvegicus
Ni2+
-
Rattus norvegicus
norepinephrine
-
Rattus norvegicus
PCMB
-
Rattus norvegicus
phosphate
-
Rattus norvegicus
Zn2+
-
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + L-His + beta-Ala
-
996
Rattus norvegicus
ADP + phosphate + carnosine
-
996
Rattus norvegicus
-
Other publictions for EC 6.3.2.11
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744004
Peters
Intrinsic carnosine metabolis ...
Homo sapiens
Amino Acids
47
2541-2550
2015
-
-
-
-
-
-
-
-
-
1
-
1
-
3
-
-
-
-
-
9
-
-
1
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-
-
-
-
-
-
1
-
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-
-
1
-
-
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-
1
-
1
-
-
-
-
-
9
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
699007
Drozak
Molecular identification of ca ...
Gallus gallus, Homo sapiens, Mus musculus
J. Biol. Chem.
285
9346-9356
2010
-
-
2
-
-
-
-
21
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2
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-
7
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3
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-
4
1
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15
2
3
-
-
-
3
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-
2
-
-
-
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-
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21
-
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2
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3
-
4
1
-
15
2
3
-
-
-
3
-
-
-
-
-
-
-
21
21
713729
Sale
Effect of beta-alanine supplem ...
Homo sapiens
Amino Acids
39
321-333
2010
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
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1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651204
Nagai
Possible role of L-carnosine i ...
Rattus norvegicus
Exp. Biol. Med.
228
1138-1145
2003
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
1
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1003
Bulygina
Isolation of carnosine synthet ...
Gallus gallus, Homo sapiens
Vopr. Med. Khim.
41
27-30
1995
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
1
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1002
Crowe
Monoclonal antibody to carnosi ...
Rana pipiens
Brain Res.
538
147-151
1991
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
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-
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-
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-
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-
-
-
-
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-
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-
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-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
988
Seely
-
Inhibition of carnosine synthe ...
Bos taurus, Gallus gallus, Rattus norvegicus
Pept. Antibiot. Biosynth. Funct. (Kleinkauf H. et al. eds. )
347-352
1982
-
-
-
-
-
-
12
-
-
-
-
-
-
3
-
-
-
-
-
7
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
7
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
989
Seely
Carnosine-synthetase inhibitio ...
Gallus gallus, Rattus norvegicus
Life Sci.
30
1763-1768
1982
-
-
-
-
-
-
11
-
-
-
-
-
-
2
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
6
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
990
Wood
Purification of carnosine synt ...
Gallus gallus
Biochim. Biophys. Acta
662
138-144
1981
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
991
Kish
Regional distribution of homoc ...
Homo sapiens
J. Neurochem.
32
1629-1636
1979
-
-
-
-
-
-
1
2
-
2
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
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-
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-
1
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2
-
2
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2
-
-
2
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
1004
Harding
The subcellular distribution o ...
Mus musculus
Brain Res.
173
99-109
1979
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
4
-
-
1
-
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-
-
-
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-
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-
-
-
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-
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-
-
2
-
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-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
992
Horinishi
Purification and characterizat ...
Mus musculus
J. Neurochem.
31
909-919
1978
-
-
-
-
-
-
2
2
-
-
-
-
-
2
-
-
1
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
1
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
993
Ng
-
Regional and subcellular distr ...
Rattus norvegicus
J. Neurochem.
30
187-190
1978
-
-
-
-
-
-
-
6
3
1
-
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
6
3
1
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
994
Ng
Subcellular distribution and s ...
Gallus gallus
Comp. Biochem. Physiol. B
54
523-525
1976
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
995
Ng
Distribution of homocarnosine- ...
Gallus gallus, Mus musculus, Rana pipiens, Rattus norvegicus
Comp. Biochem. Physiol. B
54
519-521
1976
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
16
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
996
Ng
The effect of various agents i ...
Rattus norvegicus
Experientia
32
839-841
1976
1
-
-
-
-
1
13
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
13
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
997
Skaper
Some properties of a homocarno ...
Rattus norvegicus
J. Neurochem.
21
1429-1445
1973
1
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
2
-
-
5
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
2
-
-
5
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
998
Kalyankar
-
Carnosine synthetase (chick mu ...
Gallus gallus
Methods Enzymol.
17
102-105
1971
-
-
-
-
-
-
-
-
-
3
-
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-
1
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-
1
-
1
15
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-
-
-
1
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-
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-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
1
-
1
15
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
999
McManus
Studies on the formation of ca ...
Gallus gallus
Arch. Biochem. Biophys.
119
444-453
1967
-
-
-
-
-
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-
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1
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1
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1
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1
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1
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1
-
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-
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-
-
-
-
-
-
-
-
-
-
1000
Stenesh
Carnosine-anserine synthetase ...
Gallus gallus
Biochem. J.
77
575-581
1960
-
-
-
-
-
2
6
-
-
2
-
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1
-
-
1
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-
1
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1
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1
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-
-
2
-
6
-
-
-
2
-
-
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1
-
1
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1001
Kalyankar
Enzymatic synthesis of carnosi ...
Gallus gallus
J. Biol. Chem.
234
3210-3218
1959
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1
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-
1
-
1
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20
-
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-
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1
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20
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