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Literature summary for 6.3.2.11 extracted from

  • Drozak, J.; Veiga-da-Cunha, M.; Vertommen, D.; Stroobant, V.; Van Schaftingen, E.
    Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1) (2010), J. Biol. Chem., 285, 9346-9356.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.11

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293T cells Homo sapiens
expression in HEK-293T cells Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.033
-
 beta-Alanine pH 7.5, 37°C Gallus gallus
0.09
-
 beta-Alanine pH 7.5, 37°C Homo sapiens
0.1
-
 L-histidine pH 7.5, 37°C Gallus gallus
0.11
-
 L-histidine pH 7.5, 37°C Mus musculus
0.19
-
 ATP pH 7.5, 37°C Gallus gallus
0.35
-
 4-aminobutanoate pH 7.5, 37°C Gallus gallus
0.37
-
 L-histidine pH 7.5, 37°C Homo sapiens
0.39
-
 N-pi-methylhistidine pH 7.5, 37°C Gallus gallus
0.42
-
 ATP pH 7.5, 37°C Homo sapiens
0.46
-
 beta-Alanine pH 7.5, 37°C Mus musculus
0.52
-
 L-ornithine pH 7.5, 37°C Mus musculus
0.57
-
 ATP pH 7.5, 37°C Mus musculus
1.42
-
 L-lysine pH 7.5, 37°C Gallus gallus
1.59
-
 L-lysine pH 7.5, 37°C Mus musculus
1.62
-
 L-ornithine pH 7.5, 37°C Gallus gallus
1.84
-
 4-aminobutanoate pH 7.5, 37°C Homo sapiens
4.51
-
 N-pi-methylhistidine pH 7.5, 37°C Mus musculus
4.67
-
 L-lysine pH 7.5, 37°C Homo sapiens
6.44
-
 4-aminobutanoate pH 7.5, 37°C Mus musculus
7.66
-
 L-ornithine pH 7.5, 37°C Homo sapiens
24.7
-
 N-pi-methylhistidine pH 7.5, 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 SDS-PAGE Gallus gallus
430000
-
 gel filtration Mus musculus

Organism

Organism UniProt Comment Textmining
Gallus gallus D3KCC4
-
-
Homo sapiens A5YM72
-
-
Mus musculus Q6ZPS2
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Gallus gallus
-
 Homo sapiens
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain
-
 Mus musculus
-
muscle
-
 Mus musculus
-
pectoral muscle
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.119
-
-
 Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-histidine + 4-aminobutanoate
-
 Gallus gallus ADP + phosphate + homocarnosine
-
 ?
ATP + L-histidine + 4-aminobutanoate
-
 Homo sapiens ADP + phosphate + homocarnosine
-
 ?
ATP + L-histidine + 4-aminobutanoate
-
 Mus musculus ADP + phosphate + homocarnosine
-
 ?
ATP + L-histidine + beta-alanine
-
 Gallus gallus ADP + phosphate + carnosine
-
 ?
ATP + L-histidine + beta-alanine
-
 Homo sapiens ADP + phosphate + carnosine
-
 ?
ATP + L-histidine + beta-alanine
-
 Mus musculus ADP + phosphate + carnosine
-
 ?
ATP + L-lysine + beta-alanine
-
 Gallus gallus ADP + phosphate + ?
-
 ?
ATP + L-lysine + beta-alanine
-
 Homo sapiens ADP + phosphate + ?
-
 ?
ATP + L-lysine + beta-alanine
-
 Mus musculus ADP + phosphate + ?
-
 ?
ATP + L-ornithine + beta-alanine
-
 Gallus gallus ADP + phosphate + ?
-
 ?
ATP + L-ornithine + beta-alanine
-
 Homo sapiens ADP + phosphate + ?
-
 ?
ATP + L-ornithine + beta-alanine
-
 Mus musculus ADP + phosphate + ?
-
 ?
ATP + N-pi-methylhistidine + beta-alanine
-
 Gallus gallus ADP + phosphate + ?
-
 ?
ATP + N-pi-methylhistidine + beta-alanine
-
 Homo sapiens ADP + phosphate + ?
-
 ?
ATP + N-pi-methylhistidine + beta-alanine
-
 Mus musculus ADP + phosphate + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 100000, SDS-PAGE Gallus gallus
tetramer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
ATPGD1
-
 Gallus gallus
ATPGD1
-
 Homo sapiens
ATPGD1
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Gallus gallus
37
-
 assay at Homo sapiens
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Gallus gallus
7.5
-
 assay at Homo sapiens
7.5
-
 assay at Mus musculus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.0001
-
 L-ornithine pH 7.5, 37°C Homo sapiens
0.0001
-
 N-pi-methylhistidine pH 7.5, 37°C Homo sapiens
0.0002
-
 L-lysine pH 7.5, 37°C Homo sapiens
0.0003
-
 N-pi-methylhistidine pH 7.5, 37°C Mus musculus
0.0009
-
 L-lysine pH 7.5, 37°C Mus musculus
0.002
-
 ATP pH 7.5, 37°C Mus musculus
0.0026
-
 L-ornithine pH 7.5, 37°C Gallus gallus
0.003
-
 ATP pH 7.5, 37°C Homo sapiens
0.004
-
 L-lysine pH 7.5, 37°C Gallus gallus
0.004
-
 L-histidine pH 7.5, 37°C Homo sapiens
0.0066
-
 L-ornithine pH 7.5, 37°C Mus musculus
0.01
-
 L-histidine pH 7.5, 37°C Mus musculus
0.015
-
 N-pi-methylhistidine pH 7.5, 37°C Gallus gallus
0.032
-
 ATP pH 7.5, 37°C Gallus gallus
0.05
-
 4-aminobutanoate pH 7.5, 37°C Homo sapiens
0.055
-
 L-histidine pH 7.5, 37°C Gallus gallus
0.07
-
 4-aminobutanoate pH 7.5, 37°C Mus musculus
0.44
-
 4-aminobutanoate pH 7.5, 37°C Gallus gallus
1.16
-
 beta-Alanine pH 7.5, 37°C Mus musculus
1.28
-
 beta-Alanine pH 7.5, 37°C Homo sapiens
6.03
-
 beta-Alanine pH 7.5, 37°C Gallus gallus