Literature summary for 6.3.2.10 extracted from

Stamper, G.F.; Longenecker, K.L.; Fry, E.H.; Jakob, C.G.; Florjancic, A.S.; Gu, Y.G.; Anderson, D.D.; Cooper, C.S.; Zhang, T.; Clark, R.F.; Cia, Y.; Black-Schaefer, C.L.; Owen McCall, J.; Lerner, C.G.; Hajduk, P.J.; Beutel, B.A.; Stoll, V.S.
Structure-based optimization of MurF inhibitors (2006), Chem. Biol. Drug Des., 67, 58-65.

Search for more literature for 6.3.2.10

Application

Application	Comment	Organism
medicine	MurF is a potential target for antibacterial design because it is unique to bacteria and performs an essential non-redundant function in the bacterial cell	Streptococcus pneumoniae

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals of MurF with bound inhibitor	Streptococcus pneumoniae

Inhibitors

Inhibitors	Comment	Organism	Structure
2-chloro-N-(3-cyano-2-thienyl)-5-[(diethylamino)sulfonyl]benzamide	-	Streptococcus pneumoniae
2-chloro-N-(3-cyano-3,4,5,6-tetrahydro-2H-cyclopenta[b]thiophen-2-yl)-5-[(4-hydroxybutyl)sulfamoyl]benzamide	-	Streptococcus pneumoniae
2-chloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-5-(piperidin-1-ylsulfonyl)benzamide	-	Streptococcus pneumoniae
2-chloro-N-[3-cyano-5-(2-pyridin-2-ylethyl)thiophen-2-yl]-5-(morpholin-4-ylsulfonyl)benzamide	-	Streptococcus pneumoniae
5-(aminosulfonyl)-2-chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)benzamide	-	Streptococcus pneumoniae
N-(5-bromo-3-cyano-2-thienyl)-2-chloro-5-[(diethylamino)sulfonyl]benzamide	-	Streptococcus pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pneumoniae	Q8DNV6	-	-

Synonyms

Synonyms	Comment	Organism
MurF	-	Streptococcus pneumoniae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0025	-	-	Streptococcus pneumoniae	2-chloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-5-(piperidin-1-ylsulfonyl)benzamide
0.006	-	-	Streptococcus pneumoniae	2-chloro-N-[3-cyano-5-(2-pyridin-2-ylethyl)thiophen-2-yl]-5-(morpholin-4-ylsulfonyl)benzamide
0.0126	-	-	Streptococcus pneumoniae	N-(5-bromo-3-cyano-2-thienyl)-2-chloro-5-[(diethylamino)sulfonyl]benzamide
0.022	-	-	Streptococcus pneumoniae	2-chloro-N-(3-cyano-3,4,5,6-tetrahydro-2H-cyclopenta[b]thiophen-2-yl)-5-[(4-hydroxybutyl)sulfamoyl]benzamide
0.078	-	-	Streptococcus pneumoniae	5-(aminosulfonyl)-2-chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)benzamide
0.151	-	-	Streptococcus pneumoniae	2-chloro-N-(3-cyano-2-thienyl)-5-[(diethylamino)sulfonyl]benzamide

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)