Application | Comment | Organism |
---|---|---|
pharmacology | attractive target for development of antibacterial agents | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
expression in strain BL21(DE3) | Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
hanging-drop vapour diffusion method, purified recombinant enzyme 12.2 mg/ml, in 10 mM Tris-HCl, pH 7.4, 10 mM DTT, plus equal volume of reservoir solution: 0.1 M Bis-Tris propane buffer, pH 9.4, 18% PEG 8000, 0.12 M MgSO4, 10% glycerol, about 20 days, X-ray diffraction structure determination at 2.8 A resolution, and analysis | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Escherichia coli | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala | Escherichia coli | enzyme is part of the bacterial peptidoglycan forming group of enzymes | ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala | - |
? | |
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala | Escherichia coli K37 | enzyme is part of the bacterial peptidoglycan forming group of enzymes | ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P11880 | - |
- |
Escherichia coli K37 | P11880 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant from strain BL21(DE3) | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala | - |
? | |
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala | enzyme is part of the bacterial peptidoglycan forming group of enzymes | Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala | - |
? | |
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala | - |
Escherichia coli K37 | ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala | - |
? | |
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala | enzyme is part of the bacterial peptidoglycan forming group of enzymes | Escherichia coli K37 | ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D-Ala-D-Ala-adding enzyme | - |
Escherichia coli |
MurF | - |
Escherichia coli |
Synthetase, uridine diphosphoacetylmuramoylpentapeptide | - |
Escherichia coli |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase | - |
Escherichia coli |
UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase | - |
Escherichia coli |
UDPacetylmuramoylpentapeptide synthetase | - |
Escherichia coli |
Uridine diphosphoacetylmuramoylpentapeptide synthetase | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Escherichia coli |