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Literature summary for 6.3.2.10 extracted from

  • Yan, Y.; Munshi, S.; Li, Y.; Pryor, K.A.; Marsilio, F.; Leiting, B.
    Crystallization and preliminary X-ray analysis of the Escherichia coli UDP-MurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (MurF) (1999), Acta Crystallogr. Sect. D, 55, 2033-2034.
    View publication on PubMed

Application

Application Comment Organism
pharmacology attractive target for development of antibacterial agents Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
expression in strain BL21(DE3) Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapour diffusion method, purified recombinant enzyme 12.2 mg/ml, in 10 mM Tris-HCl, pH 7.4, 10 mM DTT, plus equal volume of reservoir solution: 0.1 M Bis-Tris propane buffer, pH 9.4, 18% PEG 8000, 0.12 M MgSO4, 10% glycerol, about 20 days, X-ray diffraction structure determination at 2.8 A resolution, and analysis Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Escherichia coli 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala Escherichia coli enzyme is part of the bacterial peptidoglycan forming group of enzymes ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala
-
?
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala Escherichia coli K37 enzyme is part of the bacterial peptidoglycan forming group of enzymes ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli P11880
-
-
Escherichia coli K37 P11880
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant from strain BL21(DE3) Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala
-
Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala
-
?
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala enzyme is part of the bacterial peptidoglycan forming group of enzymes Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala
-
?
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala
-
Escherichia coli K37 ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala
-
?
ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala-D-Ala enzyme is part of the bacterial peptidoglycan forming group of enzymes Escherichia coli K37 ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala
-
?

Synonyms

Synonyms Comment Organism
D-Ala-D-Ala-adding enzyme
-
Escherichia coli
MurF
-
Escherichia coli
Synthetase, uridine diphosphoacetylmuramoylpentapeptide
-
Escherichia coli
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase
-
Escherichia coli
UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase
-
Escherichia coli
UDPacetylmuramoylpentapeptide synthetase
-
Escherichia coli
Uridine diphosphoacetylmuramoylpentapeptide synthetase
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
Escherichia coli