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Literature summary for 6.3.1.9 extracted from

  • Ondarza, R.N.; Hernandez, E.; Iturbe, A.; Hurtado, G.; Tamayo, E.M.
    Detection by HPLC of a trypanothione synthetase activity in vitro from Entamoeba histolytica (1999), Biotechnol. Appl. Biochem., 30, 41-45.
No PubMed abstract available
Search for more literature for 6.3.1.9

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity Entamoeba histolytica
Mg2+ required for activity Crithidia luciliae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gamma-L-glutamyl-L-cysteinyl-glycine + N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ATP Entamoeba histolytica
-
 N1,N8-bis-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate
-
 ?
gamma-L-glutamyl-L-cysteinyl-glycine + N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ATP Crithidia luciliae
-
 N1,N8-bis-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Crithidia luciliae
-
-
-
Entamoeba histolytica
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate, DEAE-cellulose, partially purified Entamoeba histolytica
ammonium sulfate, DEAE-cellulose, partially purified Crithidia luciliae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gamma-L-glutamyl-L-cysteinyl-glycine + N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ATP
-
 Entamoeba histolytica N1,N8-bis-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate
-
 ?
gamma-L-glutamyl-L-cysteinyl-glycine + N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ATP
-
 Crithidia luciliae N1,N8-bis-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
T(SH)2 synthetase
-
 Entamoeba histolytica
T(SH)2 synthetase
-
 Crithidia luciliae