Literature summary for 6.3.1.8 extracted from

Lin, C.H.; Chen, S.; Kwon, D.S.; Coward, J.K.; Walsh, C.T.
Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase (1997), Chem. Biol., 4, 859-866.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N1-glutathionylspermidine analogs	selective inhibitors against EC 6.3.1.8 and EC 3.5.1.78 activities provide evidence of interdomain communication in the bifunctional enzyme	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	the enzyme is bifunctional and also catalyzes the glutathionylspermidine amidase reaction, EC 3.5.1.78, resulting in a net hydrolysis of ATP	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
gamma-L-Glu-L-Cys-Gly + spermidine + ATP	-	Escherichia coli	N1-(gamma-L-Glu-L-Cys-Gly)-spermidine + ADP + phosphate	-	?

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Release 2023.1 (January 2023)