Protein Variants | Comment | Organism |
---|---|---|
additional information | knockout of Plasmodium falciparum LplA1 failed because the protein is essential for growth of parasite | Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
apicoplast | - |
Plasmodium falciparum | 20011 | - |
apicoplast | - |
Plasmodium berghei | 20011 | - |
mitochondrion | - |
Plasmodium falciparum | 5739 | - |
mitochondrion | - |
Plasmodium berghei | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
SDS-PAGE | Plasmodium falciparum |
45000 | - |
SDS-PAGE | Plasmodium berghei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium berghei | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-lipoic acid | - |
Plasmodium falciparum | diphosphate + D-lipoyl-AMP | - |
? | |
ATP + D-lipoic acid | - |
Plasmodium berghei | diphosphate + D-lipoyl-AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipoic acid protein ligase | - |
Plasmodium falciparum |
lipoic acid protein ligase | - |
Plasmodium berghei |
lipoic acid protein ligase A1 | - |
Plasmodium falciparum |
lipoic acid protein ligase A1 | - |
Plasmodium berghei |
LplA1 | - |
Plasmodium falciparum |
LplA1 | - |
Plasmodium berghei |
Lpla2 | - |
Plasmodium falciparum |
Lpla2 | - |
Plasmodium berghei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Plasmodium falciparum | |
ATP | - |
Plasmodium berghei |
General Information | Comment | Organism |
---|---|---|
malfunction | LplA1 knockout cannot be achieved because of the essential function of the gene/protein in asexual parasite growth | Plasmodium berghei |
metabolism | LplA1 plays a critical role for asexual parasite growth in vitro and in vivo. | Plasmodium berghei |
metabolism | LplA1 plays a pivotal role during the development of the erythrocytic stages of the malaria parasite. | Plasmodium falciparum |
physiological function | LplA1 plays a pivotal role during the development of the erythrocytic stages (asexual parasite growth) of Plasmodium falciparum | Plasmodium falciparum |