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Literature summary for 6.3.1.2 extracted from
- Glutamine synthetase from mammalian tissues (1985), Methods Enzymol., 113, 185-199.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| alpha-ketoglutarate | activates | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ala | - |
Rattus norvegicus | |
| Carbamoyl phosphate | - |
Rattus norvegicus | |
| Gly | - |
Rattus norvegicus | |
| L-methionine sulfoximine | - |
Rattus norvegicus | |
| L-methionine sulfoximine | - |
Sus scrofa | |
| Ser | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.18 | - |
NH4+ | Mg2+-stimulated | Ovis aries | |
| 2.3 | - |
ATP | ATP, Mg2+-stimulated | Ovis aries | |
| 2.5 | - |
ATP | L-Glu, Mg2+-stimulated | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | at pH 7.2, Mg2+ is more effective than Co2+ | Rattus norvegicus | |
| Mg2+ | - |
Sus scrofa | |
| Mg2+ | at pH 7.2, Mg2+ is more effective than Mn2+ | Rattus norvegicus | |
| Mn2+ | at pH 7.2, Mg2+ is more effective than Mn2+ | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 44000 | - |
x * 44000, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetulus griseus | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mammalia | - |
- |
- |
| Ovis aries | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Sus scrofa | - |
| brain | - |
Ovis aries | - |
| liver | - |
Gallus gallus | - |
| liver | - |
Cricetulus griseus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| neural retina | - |
Gallus gallus | - |
| spleen | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 8.93 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Glu + NH4+ | - |
Gallus gallus | ADP + phosphate + L-Gln | - |
? | |
| ATP + L-Glu + NH4+ | - |
Cricetulus griseus | ADP + phosphate + L-Gln | - |
? | |
| ATP + L-Glu + NH4+ | - |
Mammalia | ADP + phosphate + L-Gln | - |
? | |
| ATP + L-Glu + NH4+ | - |
Homo sapiens | ADP + phosphate + L-Gln | - |
? | |
| ATP + L-Glu + NH4+ | - |
Sus scrofa | ADP + phosphate + L-Gln | - |
? | |
| ATP + L-Glu + NH4+ | enzyme can bind 8 M of ATP per mol of enzyme | Ovis aries | ADP + phosphate + L-Gln | - |
? | |
| ATP + L-Glu + NH4+ | 1 mol of enzyme can bind 5 M ATP | Rattus norvegicus | ADP + phosphate + L-Gln | - |
? | |
| Gln + hydroxylamine + ADP | - |
Gallus gallus | gamma-Glutamylhydroxamate + NH4+ + ? | - |
? | |
| Gln + hydroxylamine + ADP | - |
Cricetulus griseus | gamma-Glutamylhydroxamate + NH4+ + ? | - |
? | |
| Gln + hydroxylamine + ADP | - |
Homo sapiens | gamma-Glutamylhydroxamate + NH4+ + ? | - |
? | |
| Gln + hydroxylamine + ADP | - |
Rattus norvegicus | gamma-Glutamylhydroxamate + NH4+ + ? | - |
? | |
| Gln + hydroxylamine + ADP | - |
Sus scrofa | gamma-Glutamylhydroxamate + NH4+ + ? | - |
? | |
| Gln + hydroxylamine + ADP | - |
Ovis aries | gamma-Glutamylhydroxamate + NH4+ + ? | - |
? | |
| Gln + hydroxylamine + ADP | ADP or ATP required | Mammalia | gamma-Glutamylhydroxamate + NH4+ + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 44000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
optimum varies from about pH 4.8 to 8.5 depending upon the nature and concentration of the divalent cation present | Rattus norvegicus |
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