Literature summary for 6.3.1.13 extracted from

Williams, L.; Fan, F.; Blanchard, J.S.; Raushel, F.M.
Positional isotope exchange analysis of the Mycobacterium smegmatis cysteine ligase (MshC) (2008), Biochemistry, 47, 4843-4850.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP	Mycolicibacterium smegmatis	the product 1D-myo-inositol 2-(L-cysteinyl)amido-2-deoxy-alpha-D-glucopyranoside is an intermediate in the biosynthetic pathway of mycothiol. Mycothiol is produced by Mycobacterium tuberculosis to maintain an intracellular reducing environment and protect against oxidative and antibiotic induced stress. The biosynthesis of mycothiol is essential for cell growth	1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol + AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mycolicibacterium smegmatis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP	the product 1D-myo-inositol 2-(L-cysteinyl)amido-2-deoxy-alpha-D-glucopyranoside is an intermediate in the biosynthetic pathway of mycothiol. Mycothiol is produced by Mycobacterium tuberculosis to maintain an intracellular reducing environment and protect against oxidative and antibiotic induced stress. The biosynthesis of mycothiol is essential for cell growth	Mycolicibacterium smegmatis	1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol + AMP + diphosphate	-	?
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP	positional isotope exchange analysis confirms that MshC catalyzes the formation of a kinetically competent cysteinyl-adenylate intermediate after the addition of ATP and cysteine	Mycolicibacterium smegmatis	1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol + AMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
MshC	-	Mycolicibacterium smegmatis

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Release 2023.1 (January 2023)