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Literature summary for 6.3.1.1 extracted from
- Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase (1998), Nat. Struct. Biol., 5, 15-19.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure of native AsnA and complexed with L-asparagine and AMP at 2.5 A, 2.2 A and 2.2 A resolution, respectively | Escherichia coli |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C315A | no change in activity, necessary to improve crystallization | Escherichia coli |
| C51A | no change in activity, necessary to improve crystallization | Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-aspartate + NH3 | Escherichia coli | - |
AMP + diphosphate + L-asparagine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-aspartate + NH3 | - |
Escherichia coli | AMP + diphosphate + L-asparagine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | crystallization | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ammonia-dependent asparagine synthetase | - |
Escherichia coli |
| AsnA | - |
Escherichia coli |
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