Literature summary for 6.2.2.2 extracted from

Gu, W.; Sardar, D.; Pierce, E.; Schmidt, E.W.
Roads to Rome role of multiple cassettes in cyanobactin RiPP biosynthesis (2018), J. Am. Chem. Soc., 140, 16213-16221 .

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Organism

Organism	UniProt	Comment	Textmining
uncultured Prochloron sp. 06037A	B2KYG8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [TruE]-(L-amino acyl-L-cysteine)	natural substrate is TruE carrying precursor peptides for patellin 3 and patellin 2	uncultured Prochloron sp. 06037A	ADP + phosphate + [TruE]-(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline	-	?
additional information	TruD is distributive and stochastic, with no preferred modification order. Under reductive conditions, TruD reacts with the cleaved peptide fragments and heterocyclizes them to completion. Without the addition of reducing agents, the reaction is inhibited. Recognition sequence RSI is not absolutely required for TruD activity, but greatly accelerates the reaction	uncultured Prochloron sp. 06037A	?	-	-

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Release 2023.1 (January 2023)