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Literature summary for 6.2.2.2 extracted from

  • Melby, J.O.; Dunbar, K.L.; Trinh, N.Q.; Mitchell, D.A.
    Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase (2012), J. Am. Chem. Soc., 134, 5309-5316 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.2.2

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Bacillus sp. Al Hakam

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [BalhA1]-(L-amino acyl-L-cysteine) Bacillus sp. Al Hakam
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 ADP + phosphate + [BalhA1]-(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline
-
 ?
additional information Bacillus sp. Al Hakam BalhD thiazole/oxazole synthetase modifies substrate BalhA1 in a unique C- to N-terminal overall direction. The enzyme shows a modest bias for glycine at the preceding (-1) position and a remarkable flexibility in the following (+1) position, even allowing for the incorporation of charged amino acids and bisheterocyclization ?
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Organism

Organism UniProt Comment Textmining
Bacillus sp. Al Hakam
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [BalhA1 variant C40S]-(L-amino acyl-L-serine)
-
 Bacillus sp. Al Hakam ADP + phosphate + [BalhA1 variant C40S]-(S,S)-2-(Csubstituted-aminomethyl)-4-acyl-2-oxazoline
-
 ?
ATP + [BalhA1 variant C40T]-(L-amino acyl-L-threonine)
-
 Bacillus sp. Al Hakam ADP + phosphate + [BalhA1 variant C40T]-(S,S)-2-(C-substituted-aminomethyl)-4-acyl-5-methyl-2-oxazoline
-
 ?
ATP + [BalhA1]-(L-amino acyl-L-cysteine)
-
 Bacillus sp. Al Hakam ADP + phosphate + [BalhA1]-(1S,4R)-2-(C-substituted-aminomethyl)-4-acyl-2-thiazoline
-
 ?
additional information BalhD thiazole/oxazole synthetase modifies substrate BalhA1 in a unique C- to N-terminal overall direction. The enzyme shows a modest bias for glycine at the preceding (-1) position and a remarkable flexibility in the following (+1) position, even allowing for the incorporation of charged amino acids and bisheterocyclization Bacillus sp. Al Hakam ?
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Synonyms

Synonyms Comment Organism
BalhC
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 Bacillus sp. Al Hakam
balhD
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 Bacillus sp. Al Hakam