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Literature summary for 6.2.1.76 extracted from
- A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii--cloning, sequencing, and expression of the enzymes in Escherichia coli (1998), Eur. J. Biochem., 257, 395-402 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Rhizobium leguminosarum |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0267 | - |
CoA | pH and temperature not specified in the publication | Rhizobium leguminosarum |  |
| 0.0338 | - |
ATP | pH and temperature not specified in the publication | Rhizobium leguminosarum | |
| 0.113 | - |
malonate | pH and temperature not specified in the publication | Rhizobium leguminosarum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 54612 | - |
calculated from sequence | Rhizobium leguminosarum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + malonate + CoA | Rhizobium leguminosarum | - |
AMP + diphosphate + malonyl-CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rhizobium leguminosarum | Q9ZIP5 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rhizobium leguminosarum |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 35.46 | - |
pH and temperature not specified in the publication | Rhizobium leguminosarum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 2-methylmalonate + CoA | activity is 20.4% compared to the activity with malonate | Rhizobium leguminosarum | AMP + diphosphate + 2-methylmalonyl-CoA | - |
? | |
| ATP + malonate + CoA | - |
Rhizobium leguminosarum | AMP + diphosphate + malonyl-CoA | - |
? | |
| additional information | no activity for acetate, propionate and succinate in place of malonate, and for GTP, CTP and AMP in place of ATP | Rhizobium leguminosarum | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 54612, calculated from sequence | Rhizobium leguminosarum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| malonyl-CoA synthetase | - |
Rhizobium leguminosarum |
| matB | - |
Rhizobium leguminosarum |
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