Literature summary for 6.2.1.71 extracted from

Ehmann, D.; Shaw-Reid, C.; Losey, H.; Walsh, C.
The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase Sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates (2000), Proc. Natl. Acad. Sci. USA, 97, 2509-2514 .

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P10378	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 2,3-dihydroxybenzoate + [aryl-carrier protein domain of EntB]	-	Escherichia coli	AMP + diphosphate + 2,3-dihydroxybenzoyl-[aryl-carrier protein domain of EntB]	-	?
ATP + salicylate + holo-[aryl-carrier protein domain of EntB]	-	Escherichia coli	AMP + diphosphate + salicyl-[aryl-carrier protein domain of EntB]	-	?
ATP + salicylate + holo-[aryl-carrier protein domain of SrfB1]	SrfB1, i.e. peptidyl carrier protein of surfactin synthetase	Escherichia coli	AMP + diphosphate + salicyl-[aryl-carrier protein domain of SrfB1]	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.008	-	salicylate	acceptor aryl-carrier protein domain of SrfB1, pH 7.5, 37°C	Escherichia coli
2.15	-	salicylate	acceptor aryl-carrier protein domain of EntB, pH 7.5, 37°C	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	enterobactin, the tris-(N-(2,3-dihydroxybenzoyl)serine) trilactone siderophore of Escherichia coli, is synthesized by a three-protein (EntE, B, F) six-module nonribosomal peptide synthetase	Escherichia coli

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Release 2023.1 (January 2023)