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Literature summary for 6.2.1.66 extracted from
- Sequence and genetic organization of a Bacillus subtilis operon encoding 2,3-dihydroxybenzoate biosynthetic enzymes (1996), Gene, 178, 119-123 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene dhbF, genetic organization of the Bacillus subtilis operon encoding 2,3-dihydroxybenzoate biosynthetic enzymes, cloning from a Bacillus subtilis YAC library, DNA and amino acid sequence determination and analysis, the dhb genes are located near 291° on the Bacillus subtilis chromosome | Bacillus subtilis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Bacillus subtilis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (glycyl)adenylate + holo-[glycyl-carrier protein] | Bacillus subtilis | - |
AMP + glycyl-[glycyl-carrier protein] | - |
ir | |
| (glycyl)adenylate + holo-[glycyl-carrier protein] | Bacillus subtilis 168 | - |
AMP + glycyl-[glycyl-carrier protein] | - |
ir | |
| ATP + glycine | Bacillus subtilis | - |
diphosphate + (glycyl)adenylate | - |
ir | |
| ATP + glycine | Bacillus subtilis 168 | - |
diphosphate + (glycyl)adenylate | - |
ir | |
| ATP + glycine + holo-[glycyl-carrier protein] | Bacillus subtilis | - |
AMP + diphosphate + glycyl-[glycyl-carrier protein] | - |
ir | |
| ATP + glycine + holo-[glycyl-carrier protein] | Bacillus subtilis 168 | - |
AMP + diphosphate + glycyl-[glycyl-carrier protein] | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | P45745 | corrected sequence | - |
| Bacillus subtilis 168 | P45745 | corrected sequence | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (glycyl)adenylate + holo-[glycyl-carrier protein] | - |
Bacillus subtilis | AMP + glycyl-[glycyl-carrier protein] | - |
ir | |
| (glycyl)adenylate + holo-[glycyl-carrier protein] | - |
Bacillus subtilis 168 | AMP + glycyl-[glycyl-carrier protein] | - |
ir | |
| ATP + glycine | - |
Bacillus subtilis | diphosphate + (glycyl)adenylate | - |
ir | |
| ATP + glycine | - |
Bacillus subtilis 168 | diphosphate + (glycyl)adenylate | - |
ir | |
| ATP + glycine + holo-[glycyl-carrier protein] | - |
Bacillus subtilis | AMP + diphosphate + glycyl-[glycyl-carrier protein] | - |
ir | |
| ATP + glycine + holo-[glycyl-carrier protein] | - |
Bacillus subtilis 168 | AMP + diphosphate + glycyl-[glycyl-carrier protein] | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dhbF | - |
Bacillus subtilis |
| dimodular nonribosomal peptide synthase | UniProt | Bacillus subtilis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 4'-phosphopantetheine | - |
Bacillus subtilis | |
| ATP | - |
Bacillus subtilis | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | disruption of chromosomal dhb genes results in 2,3-dihydroxybenzoate (DHB) deficiency | Bacillus subtilis |
| physiological function | enzyme DhbF is involved in the addition of glycine to the siderophore 2,3-dihydroxybenzoate (DHB). Under iron-limiting conditions, Bacillus subtilis produces DHB to acquire extracellular iron | Bacillus subtilis |
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