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Literature summary for 6.2.1.64 extracted from

  • Gong, L.; Yeh, E.
    Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway (1999), J. Biol. Chem., 274, 12036-12042 .
    View publication on PubMed
Search for more literature for 6.2.1.64

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine Saccharomyces cerevisiae
-
 AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine
-
 ?
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine Saccharomyces cerevisiae
-
 AMP + diphosphate + [UBC12]-S-[NEDD8 protein]-yl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q99344
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose column chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine
-
 Saccharomyces cerevisiae AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine
-
 ?
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine
-
 Saccharomyces cerevisiae AMP + diphosphate + [UBC12]-S-[NEDD8 protein]-yl-L-cysteine
-
 ?

Subunits

Subunits Comment Organism
? x * 49300, calculated from amino acid sequence Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Uba3 catalytic subunit, gene name Saccharomyces cerevisiae

pI Value

Organism Comment pI Value Maximum pI Value
Saccharomyces cerevisiae calculated from amino acid sequence
-
 5.1