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Literature summary for 6.2.1.64 extracted from

  • Yu, G.; Liu, X.; Tang, J.; Xu, C.; Ouyang, G.; Xiao, W.
    Neddylation facilitates the antiviral response in zebrafish (2019), Front. Immunol., 10, 1432 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.64

Inhibitors

Inhibitors Comment Organism Structure
MLN4924 potent and specific inhibitor Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine Danio rerio
-
 AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine
-
 Danio rerio AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
NAE
-
 Danio rerio
NEDD8 activating enzyme E1
-
 Danio rerio

General Information

General Information Comment Organism
malfunction when neddylation is blocked by the enzyme inhibitor MLN4924, the cellular and organismal antiviral response is suppressed. enzyme gene disruption increases the sensitivity of zebrafish to spring viremia of carp virus infection Danio rerio