Literature summary for 6.2.1.64 extracted from

Yang, X.; Brownell, J.E.; Xu, Q.; Zhu, F.; Ma, J.; Loke, H.K.; Rollins, N.; Soucy, T.A.; Minissale, J.J.; Thomas, M.P.; Mallender, W.D.; Dick, L.R.; Li, P.; Liao, H.
Absolute quantification of E1, ubiquitin-like proteins and Nedd8-MLN4924 adduct by mass spectrometry (2013), Cell Biochem. Biophys., 67, 139-147 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
MLN4924	the Nedd8-MLN4924 adduct is a tight-binding inhibitor of the enzyme	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine	Homo sapiens	-	AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
HisTrap column chromatography, HiTrap Q column chromatography and Superdex 75 gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine	-	Homo sapiens	AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
NAE	-	Homo sapiens
NEDD8 E1	-	Homo sapiens
NEDD8-activating enzyme	-	Homo sapiens

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Release 2023.1 (January 2023)