Protein Variants | Comment | Organism |
---|---|---|
A103D | the mutation is associated with encephalomyopathic mitochondrial DNA depletion syndrome | Homo sapiens |
G424D | the mutation is associated with encephalomyopathic mitochondrial DNA depletion syndrome | Homo sapiens |
I402Y | the mutation is associated with encephalomyopathic mitochondrial DNA depletion syndrome | Homo sapiens |
R284C | the mutation is associated with encephalomyopathic mitochondrial DNA depletion syndrome | Homo sapiens |
R40T | the mutation is associated with encephalomyopathic mitochondrial DNA depletion syndrome | Homo sapiens |
V370E | the mutation is associated with encephalomyopathic mitochondrial DNA depletion syndrome | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + succinate + CoA | Homo sapiens | - |
ADP + phosphate + succinyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9P2R7 | subunit beta | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + succinate + CoA | - |
Homo sapiens | ADP + phosphate + succinyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
succinate-CoA ligase | - |
Homo sapiens |
SUCLA2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme mutations cause the encephalomyopathic mitochondrial DNA depletion syndrome with methylmalonic aciduria | Homo sapiens |